High-Grade Gliomas (HGG) - Brief Information
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Distinct Genomic Aberrations between Low-Grade and High-Grade Gliomas of Chinese Patients
BACKGROUND Glioma is a type of tumor that develops in the central nerve system, mainly the brain. Alterations of genomic sequence and sequence segments (such as copy number variations or CNV and copy neutral loss of heterozygosities or cnLOH) are thought to be a major determinant of the tumor grade. METHODS We mapped genomic variations between low-grade and high-grade gliomas (LGG and HGG) in...
متن کاملAnalysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma
Gliomas, the most common primary brain tumor in humans, include a spectrum of disease. High-grade gliomas (HGG), such as glioblastoma, may arise from low-grade gliomas (LGG) that have a more indolent course. The process of malignant transformation (MT) of LGG to HGG is poorly understood but likely involves the activation of signaling programs that suppress apoptosis. We previously showed that S...
متن کاملAutomatic segmentation of glioma tumors from BraTS 2018 challenge dataset using a 2D U-Net network
Background: Glioma is the most common primary brain tumor, and early detection of tumors is important in the treatment planning for the patient. The precise segmentation of the tumor and intratumoral areas on the MRI by a radiologist is the first step in the diagnosis, which, in addition to the consuming time, can also receive different diagnoses from different physicians. The aim of this study...
متن کاملHigh frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan.
Biallelic mismatch repair deficiency (bMMRD) is a cancer predisposition syndrome affecting primarily individuals from consanguinous families resulting in multiple childhood cancers including high grade gliomas (HGG). This is the first study to assess the prevalence of bMMRD among patients with HGG in countries where consanguinity is high. We collected molecular and clinical information on all c...
متن کاملCancer Therapy: Clinical Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide
Purpose: Patients with high-grade gliomas (HGG) routinely receive radiation, temozolomide, and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, multicenter study to follow CD4 counts over time and determine whether low CD4 counts were associated with adverse
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